On June 11, 2006, Luciana Barroso and Matt Damon welcomed their first daughter together, Isabella Damon. They became a family of four and, little did they know at the time, the "Contagion" star would soon have his toughest critic. In 2021, Damon told E! News about Isabella's reactions to his films. "If the reviews come out and they're terrible, then she'll watch it. If they come out and they're good, she's going to pass," he quipped. Damon then went on to praise his daughter, saying, "She's looking for ammunition all the time. She's like one of the funniest people I've ever met. She's really cool."
All of his daughters are growing up so quickly, and now that Isabella is a teenager and the oldest daughter in the house, since Alexia is grown up, the actor said that parenting has become more difficult.
In 2021, Damon told Fatherly, "I can't put a foot right. My 15-year-old, especially. I am so uncool. ... She's actually one of the funniest people I know, which makes it worse because she just crushes me." The actor said that he still had a little more time with his two youngest daughters before they reached their teen years, and that he's thankful he got to spend more time with Isabella during the pandemic. "[The pandemic was] a time when she should be starting to push away and do her own thing. On a selfish level, I'm kind of happy," he remarked.